This chapter offers more insight into the challenge of combining information and communication technology with Inquiry Web-Based Learning and procedural guidance in order to increase the students’ involvement and responsibility for their own learning of complex science topics. The main goal of the present study is to integrate technology and inquiry into science classrooms to assist students build their own knowledge and answer meaningful driving questions.

This research lends evidence to questions regarding the value of students engaging in on-line inquiry learning to enhance science content understanding. The conclusions drawn in this work present a positive and promising path in the design of instructional processes capable to enhance students’ digital literacy and, consequently, improve student’s content understanding using web information.